CURRICULUM VITAE

Neal W. White, M.D.

Dr. White completed his B.S. at the University of Santa Clara, his M.D. at the University of Arizona, his cardiology training at U.C. San Francisco, and his interventional cardiology training at Sequoia Hospital with a pioneer in angioplasty. Dr. White is an expert in intravascular ultrasound, a technique he helped develop while at UCSF. He performed the first coronary atherectomy in the East Bay in 1989. Dr. White is Vice Chairman of Internal Medicine at John Muir Medical Center and Director of the Cardiac Cath Lab at San Ramon Regional Medical Center.

General and Interventional Cardiology
Vice Chairman, Dept. of Internal Medicine, John Muir Medical Center
Director, Cardiac Catheterization Lab, San Ramon Regional Medical Center

PERSONAL INFORMATION
Business Address \ Mailing Address

Cardiovascular Consultants Medical Group
106 La Casa Via, Suite 140
Walnut Creek, CA 94598
Phone: (925) 274-2860 Office
(925) 932-4527 Fax

EDUCATION

High School Brophy College Preparatory 1969 - 1973
Phoenix, AZ

College University of Santa Clara 1973 - 1977
Santa Clara, CA
B.S. Biology, Cum Laude

Medical University of Arizona 1977 - 1981
Tucson, AZ

POSTGRADUATE TRAINING

Intern Straight Internal Medicine 1981 - 1982
University of Arizona Affiliated Hospitals
Tucson, AZ (Rubin Bressler, MD)

Resident Internal Medicine 1982 - 1984
University of Arizona Affiliated Hospitals
Tucson, AZ (Rubin Bressler, MD)

Chief Resident Internal Medicine 1984 - 1985
University of Arizona Affiliated Hospitals
Tucson, AZ (Rubin Bressler, MD)

Research Fellow Cardiovascular Research Institute 1985 - 1986
University of California San Francisco
San Francisco, CA (Richard Havel, MD)

Clinical Fellow Cardiology 1986 - 1988
University of California San Francisco
San Francisco, CA (William Parmley, MD)

Interventional Cardiovascular Research Institute 1988 - 1989
Fellow University of California San Francisco
Sequoia Hospital
Redwood City, CA (John B. Simpson, MD, PhD)

SPECIAL SKILLS

Interventional Cardiology, Percutaneous Coronary and Peripheral Interventions, Permanent Pacemaker Implantation.

Clinical Consultant
CVIS-Cardiovascular Imaging Systems 1988 - 1993
595 North Pastoria Avenue
Sunnyvale, CA 94086
Cardiometrics 1989 - 1996
645 Clyde Avenue
Mountain View, CA 94043
Seimans Ultrasound 1991 - 1993
San Ramon, CA 94583

National Speakers Bureau
Merck Pharmaceuticals 1994 - present Parke-Davis Pharmaceuticals 1995 - present
Bristol-Meyers Squibb Pharmaceuticals 1996 - present
Berlex Pharmaceuticals 1997 - present
Cor Therapeutics 1998 - present
Certified Manufactures Clinical Proctor
Directional Atherectomy (DVI) 1990 - present
Rotational Atherectomy (Rotablator) 1996 - present
Johnson Johnson/Cordis Coronary 1996 - present
and Peripheral Stents

ACADEMIC APPOINTMENTS

Instructor 1984 - 1985
Department of Internal Medicine
University of Arizona (Rubin Bressler, MD)

Clinical Assistant Professor 1990 - 1993
University of California Davis (Martinez, VA)

HOSPITAL AFFILIATIONS

John Muir Medical Center (Active) 1989 - present
Walnut Creek, CA 94598

Sequoia Hospital (Courtesy) 1989 - present
Redwood City, CA 94061

San Ramon Regional Medical Center (Active) 1990 - present
San Ramon, CA 94583

Mt. Diablo Medical Center (Courtesy) 1993 - present
Concord, CA 94520

Golden State Rehabilitation Hospital (Courtesy) 1990 - present
San Ramon, CA 94583


Valley Medical Center (Courtesy) 1997 - present
Pleasanton, CA 94588

SOCIETY AFFILIATIONS

American Medical Association 1978 - present
American Federation for Clinical Research 1983 - 1985
American Association for the Advancement 1983
of science
American College of Physicians 1985 - present
American College of Cardiology (Fellowship) 1985 - present
American Heart Association 1989 - present
Board of Directors, Contra Costa County 1990 - 1992
Chapter of American Heart Association
Alameda Contra Costa County Medical Association 1993 - present


CERTIFICATIONS
National Board of Medical Examiners Diplomat 1982
American Board of Internal Medicine Diplomat 1984
American Board of Internal Medicine
Cardiology Subspecialty Diplomat 1988

FELLOWSHIPS
American College of Cardiology 1990

MEDICAL LICENSURES
Arizona 13471 1982 - present
California G54732 1985 - present

HONORS/AWARDS

Arizona Heart Institute 1974, 1975
Summer Undergraduate Student Fellowship
St. Joseph's Hospital and Medical Center
Phoenix, AZ (Edward Diethrich, MD)

National Aeronautics and Space Administration 1976 - 1977
Undergraduate Research Fellowship
Department of Interplanetary Biology
Ames Research Center, Moffett Field, CA
(L.I. Hichstein, PhD)

B.S. Biology Cum Laude 1977
University of Santa Clara

American Association of Anesthesiology 1981
Student Fellowship

Finalist Medical Resident Clinical Vignette 1983
Competition, American College of Physicians

Chief Medical Resident 1984 - 1985
University of Arizona Affiliated Hospitals

National Research Service Award 1985 - 1986
National Institute of Health

RESEARCH GRANTS FUNDED/EXPERIENCE

"Norepinephrine Tropic Effects on Cultured
Adult Heart Cells"
Individual NRSA, NIH 1985 - 1986
American Heart Association (CA) 1985 - 1986
CVRI Fellowship (UCSF) 1985 - 1986

"Investigation of Plaque Morphologies and
Arterial Pathology by in vivo ultrasonic tissue
Characterization"
CVRI Fellowship (UCSF) 1988 - 1989

CLINICAL TRIALS EXPERIENCE

Directional Coronary Atherectomy Device
IVUS-CVIS Device (Authored PMA for Peripheral Device)
Intravascular Doppler

Drug Trials - Antihypertensives, ACE inhibitor
Excite (xemilofiban), Opus (orofiloran)
Pacemakers: Medtronic Rate Response Study

PROFESSIONAL COMMITTEES

Legislative Committee 1978 - 1980
Medical Student Representative
American Medical Association
American Heart Association 1992 - present
Council on Clinical Cardiology
Legislative Committee 1993 - present
Alameda Contra Costa Medical Association

University Hospital, University of Arizona
Tucson, Arizona
Curriculum Committee (Third Year) 1984 - 1985
House Staff Committee (Internal Medicine) 1983 - 1985
DRG Committee 1984 - 1985

John Muir Medical Center
Walnut Creek, California
CCU committee 1989 - present
Invasive Cardiology Committee 1989 - present
Equipment Supply Subcommittee 1996 - present
Peer Review Committees
Internal Medicine 1991 - 1993
Member 1991 - 1993
Chairman 1997 - present
Cardiology 1992, 1995, 1999
Clinical Resource Management Committee 1994 - present
Congestive Heart Failure Subcommittee 1994 - present
Chest Pain Subcommittee 1994 - present
Tissue Committee 1994 - present
Department of Internal Medicine, Vice Chairman 1997 - present
Member Medical Executive Committee 1997 - present

San Ramon Regional Medical Center
San Ramon, California
Utilization Review Committee 1990 - 1992
ICU Committee 1990 - present
Pharmacy & Therapeutics Committee 1992 - 1994 &
1996 - present

Cardiac Catheterization Committee 1992 - present
Director, Cardiac Catheterization Laboratory 1992 - present

Managed Care Affiliations
Med Partners Mullikin, 1996 - 1997
Walnut Creek Regional Board
Lifeguard 1996 - 1998
Utilization Review Committee

TEACHING EXPERIENCE

Instructor, "Medical Pathophysiology" 1984 - 1985
College of Pharmacy (Michael Katz, PharmD)
University of Arizona

Instructor, "Instruction to Clinical Medicine" 1984 - 1985
Medical Preceptorship Program (Paul Rutala, MD)
University of Arizona

Instructor, "Introduction to Clinical Medicine" 1981-1982
Introduction to Physical Examination
(Paul Stillman, MD)

Intern, Resident and Chief Resident 1981 - 1985
University of Arizona


PREVIOUS PART-TIME EMPLOYMENT

Emergency Room Raymond W. Bliss Army Hospital 1982 - 1985
Physician Ft. Huachuca, AZ

Urgent Care CIGNA Health Plan 1983 - 1984
Physician Tucson, AZ

Emergency Room Veterans Administration Medical Center 1982 - 1985
Physician Tucson, AZ (Sandy Woods, MD)

Veterans Administration Medical Center 1985 - 1988
San Francisco, CA (Jose Merley, MD)

ICU and CCU Chope Medical Center 1986 - 1988
Physician San Mateo, CA

MEDICAL SPEAKING EXPERIENCE 1989 - Present

Lectured extensively at multiple venues (grand rounds, scientific sessions at National meetings, evening dinners, etc.) throughout the United States, Europe, Asia, and Australia. Topics include: Hypertension, Congestive Heart Failure, Valvular Heart Disease, Hyperlipidemia, Unstable Coronary Syndromes, Antiplatelet Therapy including 2B3A Inhibitors and ADP Blockers, Atrial Fibrillation, Malignant Ventricular Arrhythmias, Novel Interventional Coronary Devices (Atherectomy, IVUS, Doppler) and peripheral vascular interventions.

PUBLICATIONS

JOURNALS

1. Fenster PE and White NW (1982) Ventricular Septal Rupture in Acute Myocardial Infarction. Arizona Medicine 39:320-325

2. Fenster PE, White NW, Hanson CD (1985) Pharmacokinetic Evaluation of the Digoxin Amiodarone Interaction. J Am Coll Cardiol 5:108-112

3. Simpson PC, Bishopric NH, Coughlin SR, Karliner JS, Ordahl CP, Starksen NF, White NW, Williams LT (1986) An Alpha-1 Adrenergic Receptor Regulates Hypertrophy and Gene Expression of Cultured Neonatal Heart Muscle Cells. J Moll Cardiol 18(5):45-58

4. Ports TA, Srebro JP, Maneubens SM, White NW, Johnson E, Yock PG, Lo E. (1987) Simultaneous Percutaneous Aortic Valvuloplasty and Coronary Artery Angioplasty in an Elderly Patient. Am Heart Journal 115:672-674

5. White NW, Yock PG (1989) Intravascular Ultrasound: Catheter-Based Doppler and Two-dimensional Imaging in Cardiac Imaging. Card Clin North AM 7(3):525-536

6. Yock PG, Linker DT, white NW, Rowe MH, Selmon MR, Robertson CG, Hinohara T, Simpson JB (1989) Clinical Applications of Intravascular Ultrasound Imaging and Atherectomy in Intravascular Ultrasound, Techniques, Developments, and Clinical Perspectives edited by N. Bom and J. Roelandt, Klower Academic Publishers p. 117-125

7. Webb JG, Yock PG, White NW, Slepian MJ, Hui PY, Linker DT, Finkbeiner WE (1990) Intravascular Ultrasound Imaging of Normal Muscular Arteries: Significance of the Three-Layered Appearance (Circulation in press)

8. Rowe MH, Hinohara T, White NW, Robertson GC, Selmon MR, Simpson JB (1990) Comparison of Dissection Rates and Angiographic Results Following Directional Coronary Atherectomy and Coronary Angioplasty. Am J Card August 1990

9. Yock PG, Fitzgerald P, White NW, Linker DT, Angelsen BAJ (1990) Intravascular Ultrasound as a Guiding Modality for Mechanical Atherectomy and Laser Ablation. Echocardiography 7(4): 1-10

ABSTRACTS (Presented at *Regional, **National, and ***International
meetings)

*1. White NW, Diethrich EB, Purdy JG (1976) Lipoprotein Analysis of 100 Consecutive Patients Admitted to the Arizona Heart Institute Between 1974-1975. Western Intercollegiate Undergraduate Research Conference 1:6A

*2. White NW, Tomlinson GA, Hochstein LI (1977) Studies on the Thermal Activation of the ATPase Complex from Paracoccus halodenitrifans. Western Collegiate Undergraduate Research Conference 2:7A

*3. White NW, Tomlinson GA, Hochstein LI (1977) Pyruvate Metabolism and Krebs Cycle Enzyme Kinetics in Halobacterium sarcharovorum; An Extremely Halophilic Bacterium. Western Intercollegiate Undergraduate Research Conference 2:51

*4. White NW (1983) Ascending Paralysis Following a Seizure. Presented at the American College of Physicians Meeting, October 1983

**5. White NW, Fenster PE, Hanson DC (1984) Pharmacokinetic Evaluation of the Digoxin Amiodarone Interaction. J Am Coll Card 3:II-567

*6. White NW, Fenster PE (1984) Pharmacokinetic Evaluation of the Digoxin Amiodarone Interaction. Clin Res 32:15A

*7. White NW, Tsao TC, Simpson PC (1986) Differential Regulation of Myosin Isoenzyme Expression in Alpha-1 Adrenergic and Thyroid Stimulated Hypertrophy. Clin Res 34:16A

**8. White NW, Tsao TC, Simpson PC (1986) Contractile Protein Content is Increased Hypertrophy Stimulated by Norepinephrine but not by a Phorbol Ester: An Example of Pathological Hypertrophy in cultured Neonatal Rat Heart Muscles. J Am Coll Cardiol 7:II-122A


***9. Simpson PC, Bishopric NH, Coughlin SR, Karliner JS, Ordahl CP Starksen NF, White NW, Williams LT (1986) An Alpha-1 Adrenergic Receptor Regulates Hypertrophy and Gene Expression of Cultured Neonatal Heart Muscle Cells. J Mol Cell Cardiol 18:supple 1, 8

**10. White NW, Simpson PC (1986) Regulation of Myosin Accumulation in Hyper-Alpha-1 Adrenergic Receptor is Independent of Contractile Activity. Circulation 74:II-80

**11. White NW, Simpson PC (1986) Regulation of a Myosin Accumulation in Hypertrophied and Beating Cultured Neonatal Rat Heart Myocytes. Circulation 74:II-418

**12. Yock PG, Linker D, Saether H, Thapilyal H, Arenson J, White NW, Ports T, Angelsen (1988) Intravascular Two-Dimensional Catheter Ultrasound: Initial clinical studies. Circulation 78:II-21

**13. Yock PG, Linker D, Arenson J, Thapilyal HV, Saether O, White NW, Angelsen BA (1989) Intravascular 2-D ultrasound: Clinical Studies in Periphery. The international Society for Optical Engineering (Supplement, January)

**14. White N, Denardo S, Johnson, Yock P, et al (1989) Greater Improvement in Coronary Flow Velocity With Atherectomy Compared to Angioplasty. J Am Coll Cardiol 13:II-108A

**15. Simpson JB, Hinohara T, Selmon M, Robertson G, White N, Rowe M, Braden L (1989) Comparison of Early and Recent Experience in Percutaneous Coronary Atherectomy. J Am Coll Cardiol 13:II-108A

**16. Hinohara T, Selmon M, Robertson G, White N, Rowe M, Simpson JB (1989) Angiographic Appearance After Percutaneous Coronary Atherectomy. J Am Coll Cardiol 13:II-223A

**17. Robertson G, Hinohara T, Selmon M, Rowe M, White NW, Simpson JB (1989) Complications : Early Experience of Percutaneous Coronary Atherectomy. J Am Coll Cordiol 13:II-222A

**18. Selmon M, Robertson G, Hinohara T, White N, Rowe M, Simpson JB (1989) Factors Associated With Restenosis Following Successful Percutaneous Peripheral Atherectomy. J Am Coll Cardiol 13:II-13A

**19. White NW, Webb JG, Rowe MH, Selmon MR, Hinohara T, Linker DT, Yock PG (1989) Atherectomy Guidance Using Intravascular Ultrasound: Quantitation of Plaque Burden. Circulation 80:II-374

**20. Marco J, Flajadet J, Robert G, Claude Morice M, Glatt B, Leary J, White NW, Linder DT, Yock PG (1989) Intracoronary Ultrasound Imaging: Initial Clinical Trials. Circulation 80:II-374

**21. Robertson GC, Hinohara T, Selmon MR, White NW, Simpson JB (1989) Effectiveness of Directional Coronary Atherectomy for the Treatment of Ostial Lesions, Circulation 80:II-582

**22. Selmon MR, White NW, Slipperly ME, Robertson GR (1989) Efficacy and Safety of Directional Coronary Atherectomy for the Treatment of Bypass Graft Stenoses. Circulation 80:II-583

**23. White NW, Rowe M, Selmon M, Robertson G, Hinohara T, Hui P, Simpson JB (1989) Catheter Mounted Two-Dimensional Intravascular Ultrasound: Usefulness in Guiding Percutaneous Peripheral Atherectomy. Radiology 173:74

**24. Slepian MJ, White NW, Rowe MH, Webb J, Brescan O (1989) Intravascular Two-Dimensional Ultrasound: Sensitive Imaging Modality for Detection of Complete versus Partial Stent Expansion. Radiology 173:106

**25. Webb JG, Yock PG, Slepian MJ, White NW, Hui PY, Rowe MH, Linker DT, Finkbeiner WE (1990) Intravascular Ultrasound: Significance of the Three-Layered Appearance of Normal Arteries. J Am Coll Card 15:II-17A

**26. Yock PG, Fitzgerald PJ, Jang Y-T, Starksen N, White N, Linker DT, McKenzie J, Belef M, Simpson JB (1990) Initial Trials of a Combined Ultrasound Imaging/Mechanical Atherectomy Catheter. J Am Coll Card 15:II-105A